CEO respondents have since 1999 shared their most pressing concerns and responses on how to mitigate major challenges in business. The Conference Board CEO Challenge surveys CEOs around the world and has shown that leaders place high priority on agility, communication, talent, and sustainability, to name a few. This report synthesizes and details those results for CEOs, enabling them to glean big-picture analysis and trends in CEO respondents’ strategies to tackle today’s most pressing challenges.